Abstract
A group of tri and tetrasubstituted urea derivatives have been found to be hH(3)-antagonists. The most potent compounds were found in the class of (piperazine-1-yl)-(piperidine-1-yl)-methanones which in addition showed negligible hERG inhibition.
MeSH terms
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Cinnamates / chemistry*
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ERG1 Potassium Channel
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Ether-A-Go-Go Potassium Channels / antagonists & inhibitors
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Histamine Antagonists / chemical synthesis
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Histamine Antagonists / chemistry
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Histamine Antagonists / pharmacology*
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Humans
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Molecular Structure
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Receptors, Histamine H3 / drug effects*
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Stereoisomerism
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Structure-Activity Relationship
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Thiazines / chemical synthesis
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Thiazines / chemistry
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Thiazines / pharmacology*
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Urea / analogs & derivatives*
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Urea / chemical synthesis
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Urea / chemistry*
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Urea / pharmacology
Substances
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Cinnamates
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ERG1 Potassium Channel
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Ether-A-Go-Go Potassium Channels
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Histamine Antagonists
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KCNH2 protein, human
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Receptors, Histamine H3
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Thiazines
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Urea